DuPont Coder 300 DNA synthesiser, United States, 1980
The DuPont Coder 300 DNA synthesiser is seen on the right. It was used together with the Genesis 2000 sequencer (1996-310) as part of an investigation by the Institute of Food Research. The institute’s protein engineering cycle investigated the structure/function relationships in enzymes such as papain. The effects of site-specific mutations were predicted using the synthesiser. They were verified in a cloned specimen using the sequencer.
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DNA stores the information, or blueprints, of every cell and is located in the genes. It is made up of two strands which form a double helix that is linked by hydrogen bonds. It was first described in 1953 by Francis Crick and James Watson.
Glossary: DNA synthesiser
One of a group of complex organic substances formed in the living cells of plants and animals. A catalyst for the chemical reactions of biological processes.