'Pock-marked faces: A curious illusion', anti-vaccination leaflet, England, 1881-1890
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Smallpox is an infectious virus unique to humans. It results in a characteristic skin rash and fluid-filled blisters. After successful vaccination campaigns throughout the 1800s and 1900s, the World Health Organisation certified the eradication of smallpox in 1979. Smallpox is the only human infectious disease to have been completely wiped out.