How do connections between neurones become strengthened, so that the connection is 'remembered'? Scientists know that if they give an electrical impulse to a pair of neurones, the two will communicate more easily in the future. This process is known as long-term potentiation (LTP). The effect can last for weeks, or even months - long enough to make a memory. LTP is especially obvious in the hippocampus, one of the areas of the brain active in memory.