The first antidepressant was discovered by accident in the 1950s. A drug being used to treat tuberculosis patients (iproniazid) seemed to cheer them up. This drug and other related antidepressants all increase and prolong the actions of serotonin and/or noradrenaline in the brain. The best known of these is Prozacİ, which exaggerates the actions of serotonin. Helping people to overcome their negative thoughts (cognitive therapy) is also an effective way of treating depression.