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Understanding achondroplasia

Bone is made from cartilage, which is produced at the ends of limb bones as they grow. People with achondroplasia produce less cartilage, so their limbs are shorter. They have an altered version of a gene, called FGFR-3 which is the instruction for a protein that becomes overactive as a result of the change, slowing down cartilage growth.

A couple, both with achondroplasia.
A couple, both with achondroplasia.
Wellcome Photo Library

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