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How is SCID inherited?

X-linked SCID is caused by an altered gene found on the X-chromosome, so the disorder usually affects only boys. In some cases, the disease appears 'out of the blue', following a genetic change in the unfertilised egg. In others, the affected boy inherits SCID from his carrier mother. A carrier woman has a one-in-four chance of having an affected son, and a one-in-four chance of having a carrier daughter.

Inheritance of severe combined immunodeficiency.
Inheritance of severe combined immunodeficiency.

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